iS CLINICAL Active Serum Vs Super Serum Advance+

Serums are one of the most popular and effective skincare products in the market today. They are highly concentrated with ingredients that target specific skin concerns, such as aging, acne, hyperpigmentation, and more. But with so many options available, how do you choose the right serum for your skin type and goals? In this article, we will compare two of the best-selling serums from iS CLINICAL, a leading American brand that combines science and nature to create innovative formulas. These are the Active Serum and the Super Serum Advance+, which we will look at their ingredients, textures, usage, and even to price estimation. By the end of this article, you will have a clear idea of which serum is right for you and why.

We will talk about the following:

  • What are iS CLINICAL Active Serum and Super Serum Advance+?
  • What are the ingredients of iS CLINICAL Active Serum and Super Serum Advance+?
  • How are the textures of iS CLINICAL Active Serum and Super Serum Advance+?
  • How is the ideal usage of iS CLINICAL Active Serum and Super Serum Advance+?
  • What are the price differences between iS CLINICAL Active Serum and Super Serum Advance+?
  • Which one to buy?
iS CLINICAL Active SerumiS CLINICAL Super Serum Advance+
Product Dimensions 2.88 x 1.63 x 4 inches2.68 x 1.38 x 4 inches
Shipping Weight1.06 Ounces2.72 Ounces

About iS CLINICAL Active Serum and Super Serum Advance+

iS CLINICAL is a renowned skincare brand that was founded in 2002. The brand is recognized for its innovative, clean, and multitasking skincare solutions that cater to a wide variety of skin types, ages, and genders. Their products are designed to address common skincare concerns and are known for their clinically proven results and advanced formulations.

The iS CLINICAL Active Serum is one of the brand’s most popular products. It is claimed to be a fast-acting, long-term, results-oriented formula that decreases the appearance of fine lines and wrinkles, visibly evens skin tone, and is excellent for blemish-prone skin. It’s also praised for its ability to clarify and brighten the skin, making it a favorite among those with acne-prone and congested skin.

Then, the iS CLINICAL Super Serum Advance+ is another highly regarded product from the brand. It is a scientifically advanced and clinically proven age-defying, super antioxidant, and brightening serum that is claimed to be one of the best anti-agers on the market. It is effective at obliterating dark spots, stimulating collagen production, diminishing fine lines, and boosting radiance.

When comparing the two, both serums are fungal acne safe and reef safe. They are both likely to be good for brightening the skin, scar healing, and reducing dark spots. Both are also part of the iS CLINICAL’s commitment to providing science-backed skincare solutions that deliver results.However, these products also have differences you may find note-worthy.

Ingredients of iS CLINICAL Active Serum and Super Serum Advance+

iS CLINICAL Active Serum is basically a blend of botanical actives. This serum has key ingredients consisting of bilberry, a natural AHA exfoliant with moisturizing properties, then arbutin which is derived from mushrooms to assist in minimizing the appearance of uneven skin tone while brightening the overall complexion.

Then, it has Sugar Cane extract as AHA that gently exfoliates the skin for a renewed complexion and White Willow Bark to act as botanical BHA that exfoliates the skin and deeply cleans pores. These botanical extracts work together to provide a range of skincare benefits, including exfoliation, hydration, and brightening.

iS CLINICAL Super Serum Advance+ combines a 15% concentration of the next-generation L-Ascorbic Acid (Vitamin C) and basically a blend of 4 key ingredients consisting of ADVANCE+ Vitamin C which supports skin’s natural defenses and maintain its youthful glow while providing calming properties, Centella Asiatica that helps diminish the appearance of premature aging, Tripeptide-1 (Copper Tripeptide-1) to visibly reduce wrinkles over time, and Mushroom as natural antimicrobial that assists in brightening the overall complexion.

Besides these four, this serum also has other additional ingredients such as Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Arbutin, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine HCl, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid, and many more.

Textures of iS CLINICAL Active Serum and Super Serum Advance+

iS CLINICAL Active Serum has a very lightweight consistency, almost like water on the skin. It absorbs incredibly quickly and dries out within seconds. Some also said the serum is smooth and leaves the skin moist and smooth. It’s a fast-acting, long-term, results-oriented formula.

For the scent, the serum is said to have a very strong scent of alcohol and menthol. When applied, it also causes a tingling feeling on the skin. This sensation comes from the Menta extract, a natural botanical extract, used as an ingredient in the product. When this feeling happens, it signals absorption and activity.

iS CLINICAL Super Serum Advance+ is described as very thin and absorbs right into the skin. It’s watery in consistency and suitable to be used as a daily serum. However, this watery consistency has pros and cons for some users. The pros are quick absorption and time efficiency, but the cons are usage rate and application concerns as the water-like consistency might make it harder to gauge if the product has been evenly distributed on the skin or not.

For the scent, it’s mainly described to be odorless or have no fragrance at all. However, some users also notice this serum has a subtle smell of plants or witch hazel, but it’s definitely not the type of unpleasant or disturbing smell.

Ideal Usage of iS CLINICAL Active Serum and Super Serum Advance+

iS CLINICAL Active Serum and Super Serum Advance+ are both highly regarded skincare products from the same brand, but they certainly have different characteristics and uses. First, the Active Serum is known for its ability to exfoliate and clarify the skin, resulting in a complexion that’s brighter, clearer, smoother, and more refined. This serum is particularly beneficial for normal, combination, oily, acne-prone, and dull skin types.

To apply iS CLINICAL Active Serum, it’s recommended to apply a small amount to your face and neck. You can apply 3-4 drops of the Active Serum to your palm and then using your fingertips, dab and smooth evenly over your face and neck. As you do so, be prepared for a slight tingling sensation as this “active” product works its magic. This Active Serum can be used in the morning and the evening. However, caution is advised if your skin is dry, thin, or sensitized.

On the other hand, Super Serum Advance+ helps reduce the appearance of fine lines and wrinkles, improves the look of hypertrophic (raised) scar tissue and fine stretch marks, and safely brightens and helps visibly diminish uneven skin tone. To use the serum, apply 3-4 drops in the palm as well and then dab over the face and neck with your fingertips. It can be used once or twice daily, morning and/or night after cleansing and before moisturizing.

Then due to the nature of this serum containing Vitamin C, it’s strongly advised that you store Super Serum Advance in refrigerators or cool, dark space to help shelter it from oxidation. Vitamin C is sensitive to light and can degrade quickly, make sure to always protect it from UV exposure.

Price Differences between iS CLINICAL Active Serum and Super Serum Advance+

iS CLINICAL Active Serum is priced at approximately $88 for 15ml size and $142 for the full size of 30ml. Meanwhile, the Super Serum Advance+ is priced at approximately $95 for 15ml size and $158 for the full 30ml size.

This makes Super Serum Advance+ is slightly more expensive. This is most likely because this serum has a high concentration of L-ascorbic acid (Vitamin C) with a bioidentical Copper Tripeptide Growth Factor, ingredients that are known for their effectiveness in skincare but also costly to source and formulate.

iS CLINICAL Active SerumiS CLINICAL Super Serum Advance+
Features- ACTIVE SERUM™ is our most popular product. A multi-tasking serum that is a fast-acting, long-term, “results-oriented” formula.
- Excellent for all skin types and for all ages, this powerful botanical serum leaves the skin smooth.
- Improves the appearance of uneven skin tone, wrinkles, fine lines and acne. Smooths and softens the skin.
- SUPER SERUM™ ADVANCE+ combines a 15% concentration of our next generation L-ascorbic acid (vitamin C) with Tripeptide-1 (Copper Tripeptide-1), for enhanced anti-aging properties.
- Reduce signs of aging, scar tissue, stretch marks, uneven pigmentation. Stimulates collagen, promotes wound healing.
- Can be used morning and evening. For best results, follow complete iS CLINICAL skincare regime.


In the end, it can be said that both serums are commendable for their science-backed formulations, but understanding your skin concerns and preferences will guide you towards the right choice.

Active Serum is ideal for addressing blemishes and refining the skin, offering a lightweight formula with botanical actives. On the other hand, Super Serum Advance+ is a potent anti-aging option, boasting a scientifically advanced blend with a higher price tag.

Consider your skin concerns, preferences, and budget. Both products exemplify iS CLINICAL’s commitment to effective skincare, so no product is better than the other. To finally decide your final choice, make sure to choose the one that aligns the most with your needs for a personalized skincare routine.

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